LBC Diagnosis of Clear Cell Adenocarcinoma of Vagina: An Interesting Case Report
نویسندگان
چکیده
Clear cell Adenocarcinoma (CCA) of vagina is a rare malignancy, reported at early ages in daughters of mothers exposed to diethylstilbestrol (DES) in utero. Histological features are well established, however cytological findings and moreover Liquid Based Cytology (LBC) morphology is not well characterized. We report a case of primary vaginal CCA first time picked up on LBC smear examination, confirmed by further histopathology and immunohistochemistry. In this case LBC smear from a 27-year-old lady (with no maternal history suggestive of DES exposure) displayed multiple three-dimensional groups of atypical cells with abundant foamy to vacuolated cytoplasm with focal acinar formations. Subsequent histologic features from the polypoidal lesion from vagina were consistent with CCA confirmed by immunohistochemistry. This case emphasizes the role of LBC in detection of the lesion and stresses on the unique features of CCA.
منابع مشابه
Non-Diethylstilbestrol-Associated Primary Clear Cell Carcinoma of the Vagina: Two Case Reports with Immunohistochemical Studies and Literature Review
Primary clear cell adenocarcinomas most commonly involve the genitourinary system, including the vagina. Previously, primary clear cell adenocarcinomas of the vagina have been discussed within the context of prenatal exposure to diethylstilbestrol. Due to its widely proven role in the development of this carcinoma, administration of diethylstilbestrol is prohibited. We present two cases of non-...
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